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The influenza viruses are classified into types A, B and C based on their core proteins. Type A viruses infect humans and mammals such as pigs and horses, and birds.
Type B and C viruses usually affect humans. Type A and B viruses are common causes of acute respiratory infections. Type A virus is the main cause of epidemics and pandemics.
The Spanish flu in resulted in an estimated death of 40 million worldwide. The Asian influenza pandemic of and the Hong Kong influenza pandemic of caused significant mortality worldwide. The virus often mutates.
Minor mutations antigenic drift are frequent and cause repeated outbreaks. Major mutations antigenic shift are rare and are due to reassortment of genetic material from different A sub-types.
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